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Generic amlodipine vs norvasc, an early antidepressant" by R. A. Schlosser et al for American Journal of Psychiatry: "The authors found that amlodipine produced a similar antidepressant response to desipramine, but had lower sedation and tolerability compared to norvasc, an antidepressant with less selective serotonin–reuptake inhibition."
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One last word: some early animal and human studies showed that amlodipine would work as an anxiolytic. (I also mention "prostate dysfunction syndrome", of some significance in many cases, to my colleagues in Australia and the EU.)
As an aside, at the end of this posting, I mention that once worked with an Australian neuroscientist – David Gove, now at Sydney University – who was highly sensitive to what I thought about the issue. He asked me if I recalled my discussion with Dr Mucke last year. I told him yes, had R. A. Schlosser. But I had tried to change the subject in post I had written about these results – and, in the course of it, I had neglected to mention that the very next day (after that discussion had gone public) I written to the researchers in Australia informing them of the fact they had been contacted by my colleagues in England and telling them to go ahead and resubmit their work (they had by then accepted the criticism I set out in my post).
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"The results of this study suggest that amlodipine-associated clinical benefit is largely explained by an improvement in depression, as measured this study and others. The mechanism by which amlodipine alleviates depression appears to involve improved activity of the neurotransmitter serotonin, an agent known to influence the activity of glutamate and norepinephrine receptors," say the investigators, led by M. R. Sankaranarayana of the
How much does generic flagyl cost Research Institute Brain Development and Injury, University of Chicago.
Amlodipine, also known as SERT inhibitor lisproprion, is used to treat depression when conventional antidepressant treatments fail. The researchers examined more than 100 patients who had generic amlodipine besylate failed to respond amlodipine in a previous study and identified nine other patients who responded to amlodipine when used treat depression. These patients were divided into two subgroups: one that responded to amlodipine for 12 weeks and a second group that responded to amlodipine for 12 weeks and then relapsed to an untreated state.
The researchers then studied each subgroup for five months, noting any improvement in their depression. They evaluated the patients' depression using Hamilton Rating Scale for Depression (HRSD) and the Montgomery-Ă…sberg Rating Scale (MADRS). researchers also measured blood levels of the natural chemicals serotonin and norepinephrine, respectively, to see changes in their activity, which may provide insight into how amlodipine is working. At the end of each period, they compared the two subgroups' rates of relapse, noting any differences.
At the beginning and end of study, the investigators found no significant between-group differences in HRSD or MADRS scores between the two subgroups. However, they observed a significant difference within the first few weeks of treatment between the two subgroups. At end of the 12-week period, those who had received 12 weeks of amlodipine (n=9) and those who had received 12 weeks of amlodipine followed by placebo (n=9) were more likely to relapse during that period.
The researchers also measured levels of natural compounds in both the amlodipine-treated patients generic of amlodipine and placebo-treated groups' blood, with levels of serotonin, norepinephrine and others interest. By the end of study, patients who responded to 12 weeks of amlodipine (median change 5.6) had significantly higher levels of norepinephrine and lower serotonin than patients who had responded to placebo (median change of -2.1).
The authors also noted that patients who responded to amlodipine treatment showed a significant decrease in glutamate and higher levels of serotonin during the post-study period.
"The clinical benefit reported by the amlodipine group appears to be predominantly attributed improved activity of these neurotransmitter systems in the brain, with some effect on serotonin activity that may be secondary to an improved activity of glutamate neurotransmission," they write.
While the study did not show how amlodipine worked, it is possible that its effects on serotonin could be caused by increasing the expression of its receptor on the brain cells, researchers believe.
Can you buy restavit over the counter in australia This could be achieved by blocking its receptor with an antagonist such as duloxetine or by increasing the levels of dopamine or norepinephrine produced with other antidepressants, they say.
The researchers conclude that amlodipine may be effective in the treatment of patients who do not respond to antidepressant drugs. It also offers promise for the development of drugs aimed at regulating neurotransmitter system activity.
"If this finding is confirmed, it suggests that the antidepressant effects of amlodipine can be attributed almost exclusively to improved activity of serotonin receptors
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"It is important to point out that this study may not be applicable to all patients that exhibit an SSRI-receptor defect, but it is still a very promising finding in the treatment of patients with this disorder," they add. "However, further studies to clarify the mechanisms underlying antidepressant efficacy of amlodipine are urgently needed."
The researchers did not receive any financial support from anyone for this work. Dr. Sankaranarayana's coauthors include Thomas H. Reifschneider, Dr. William E. DeCasper and Daniel B. Weitz.
Reviewed by F. Perry Wilson, MD, MSCE Instructor of Medicine, Perelman School Medicine at the University of Pennsylvania and Dorothy Caputo, MA, BSN, RN, Nurse Planner
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